Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.82 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18803539 | 0.90 | MKNK1 (1.00) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL18803637 | 0.82 | MKNK1 (0.70) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL1089672 | 0.79 | CXCR4 (0.72) | MKNK1CXCR4HRH3ADRA2BADRA2C | |
| SCHEMBL18803570 | 0.78 | MKNK1 (1.00) | MKNK1MKNK2CDK2CDC7ROCK1 | |
| SCHEMBL28690595 | 0.78 | MKNK1 (0.52) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL29353130 | 0.78 | MKNK1 (0.52) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL28704767 | 0.77 | MKNK1 (0.64) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL18803525 | 0.73 | MKNK1 (1.00) | MKNK1MKNK2LCK | |
| SCHEMBL18803544 | 0.73 | MKNK1 (1.00) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL5094294 | 0.72 | MAPK8 (0.78) | MKNK1MKNK2MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113956240-A | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2022-01-21 | — | — | CN | claimed |
| CN-113956240-B | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2023-02-14 | — | — | CN | disclosed |
| CN-113956240-A | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2022-01-21 | — | — | CN | disclosed |