Sugi Predict

Sugi Predict / Compounds / SCHEMBL2893369

SCHEMBL2893369

SCHEMBL2893369

Cc1cc(C)n(-c2nc(Cl)cnc2C=O)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 1/20 0.44
▸ KMT2A Q03164 3/20 0.40
▸ HSD17B10 Q99714 2/20 0.40
▸ CYP2C9 P11712 2/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ ALDH1A1 P00352 4/20 0.40
▸ POLB P06746 2/20 0.40
▸ TSHR P16473 1/20 0.39
▸ BCL6 P41182 1/20 0.37
▸ LMNA P02545 2/20 0.37
▸ KDM4E B2RXH2 3/20 0.36
▸ HPGD P15428 2/20 0.36
▸ GAA P10253 2/20 0.36
▸ CYP1A2 P05177 2/20 0.36
▸ ALOX15 P16050 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ SLC11A2 P49281 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2891251 0.79 BCL6 (0.51) CYP2C19ALDH1A1POLBTSHRBCL6
SCHEMBL2889096 0.77 SMN1; SMN2 (0.44) HTTKMT2AHSD17B10CYP2C9MEN1
SCHEMBL2891860 0.70 HTT (0.40) HTTKMT2AHSD17B10CYP2C9MEN1
SCHEMBL25318412 0.69 HTT (0.46) HTTKMT2AHSD17B10CYP2C9MEN1
SCHEMBL22678487 0.69 KCNJ1 (0.46) KMT2AMEN1CYP2C19ALDH1A1LMNA
SCHEMBL29844672 0.69 KCNJ1 (0.46) KMT2AMEN1CYP2C19ALDH1A1LMNA
SCHEMBL2889620 0.69 BCL6 (0.57) HTTKMT2AHSD17B10CYP2C9MEN1
SCHEMBL25942572 0.67 HSD17B10 (0.50) HTTKMT2AHSD17B10CYP2C9MEN1
SCHEMBL2891461 0.66 HTT (0.51) HTTKMT2AHSD17B10CYP2C9MEN1
SCHEMBL23214420 0.66 ALDH1A1 (0.39) KMT2AMEN1CYP2C19ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8415358-B2 Pyrazine derivatives and their use as potassium channel modulators NEUROSEARCH A/S (DK) 2013-04-09 — — US disclosed
US-8415358-B2 Pyrazine derivatives and their use as potassium channel modulators NEUROSEARCH A/S (DK) 2013-04-09 — — US disclosed
US-8415358-B2 Pyrazine derivatives and their use as potassium channel modulators NEUROSEARCH A/S (DK) 2013-04-09 — — US disclosed
US-20100286161-A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS CADENT THERAPEUTICS, INC. 2010-11-11 — — US disclosed
US-20100286161-A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS CADENT THERAPEUTICS, INC. 2010-11-11 — — US disclosed
US-20100286161-A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS CADENT THERAPEUTICS, INC. 2010-11-11 — — US disclosed
EP-2203436-A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2010-07-07 — — EP disclosed
WO-2009037247-A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2009-03-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286161-A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS KCNJ2, KCNQ5, KCNA5 HTT 855/4885KMT2A 650/4885HSD17B10 3090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.