Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702758 | 0.79 | KCNH2 (0.47) | — | |
| Bromide SCHEMBL6568584 | 0.73 | LMNA (0.37) | TP53 | |
| Bromide SCHEMBL11544836 | 0.73 | KCNH2 (0.38) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6669906 | 0.70 | LMNA (0.38) | TP53TAAR1 | |
| SCHEMBL7481443 | 0.69 | — | — | |
| Bromide SCHEMBL19063544 | 0.69 | HDAC8 (0.44) | TP53 | |
| SCHEMBL2638997 | 0.68 | TP53 (0.36) | TP53 | |
| Bromide SCHEMBL10904035 | 0.67 | TP53 (0.39) | TP53 | |
| Bromide SCHEMBL6738889 | 0.67 | TP53 (0.39) | TP53 | |
| Iodide SCHEMBL7311521 | 0.67 | TP53 (0.39) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115465902-A | Reaction solvent for preparing superfine nickel oxide nanoparticles and method for preparing superfine nickel oxide by using reaction solvent | 河北科技大学 | 2022-12-13 | — | — | CN | claimed |