SCHEMBL28937893

SCHEMBL28937893

O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1-c1cccc(Cl)c1

nearest known ligand 0.67

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TYMS P04818 1/20 0.61
LMNA P02545 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
TK1 P04183 1/20 0.59
ALOX12 P18054 1/20 0.56
ADRA1A P35348 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30083719 1.00 TYMS (0.61) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL28937859 0.90 LMNA (0.66) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL5872460 0.88 TYMS (0.76) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL5872464 0.88 TYMS (0.76) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL5982466 0.88 TYMS (0.76) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL5982470 0.88 TYMS (0.76) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL19777590 0.88 TYMS (0.76) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL13273335 0.88 TYMS (0.76) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL20456162 0.88 TYMS (0.63) TYMSLMNASMN1; SMN2TK1ALOX12
SCHEMBL28963437 0.88 LMNA (0.65) TYMSLMNASMN1; SMN2TK1ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115611816-A Method for efficiently preparing 5-aryl (hetero) ring modified uracil derivative 中国科学院化学研究所 2023-01-17 CN disclosed