Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 3/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.44 |
| ▸ | PDE5A | O76074 | 12/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481207 | 1.00 | P2RX3 (0.44) | P2RX3P2RX2PDE5ACLK4MAPK1 | |
| SCHEMBL22714768 | 0.90 | P2RX3 (0.45) | P2RX3P2RX2PDE5ACLK4MAPK1 | |
| SCHEMBL29481339 | 0.90 | P2RX3 (0.45) | P2RX3P2RX2PDE5ACLK4MAPK1 | |
| SCHEMBL28726527 | 0.88 | P2RX3 (0.45) | P2RX3P2RX2PDE5ACLK4MAPK1 | |
| SCHEMBL29481254 | 0.88 | P2RX3 (0.45) | P2RX3P2RX2PDE5ACLK4MAPK1 | |
| SCHEMBL29481280 | 0.85 | CLK4 (0.40) | PDE5ACLK4MAPK1USP2LMNA | |
| SCHEMBL22714717 | 0.85 | CLK4 (0.40) | PDE5ACLK4MAPK1USP2LMNA | |
| SCHEMBL28726614 | 0.83 | CLK4 (0.39) | PDE5ACLK4MAPK1USP2LMNA | |
| SCHEMBL29481335 | 0.83 | CLK4 (0.39) | PDE5ACLK4MAPK1USP2LMNA | |
| SCHEMBL29481199 | 0.82 | CLK4 (0.42) | PDE5ACLK4MAPK1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239931-A | As P2X3Aminoquinazoline derivatives of inhibitors | 奇斯药制品公司 | 2024-06-25 | — | — | CN | claimed |
| CN-114269432-B | As P2X3Aminoquinazoline derivatives of inhibitors | 奇斯药制品公司 | 2024-05-07 | — | — | CN | claimed |
| CN-114269432-A | As P2X3Aminoquinazoline derivatives as inhibitors | 奇斯药制品公司 | 2022-04-01 | — | — | CN | claimed |