⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655477 | 0.98 | KCNH2 (0.38) | — | |
| Hydrochloric Acid SCHEMBL27843088 | 0.98 | KCNH2 (0.38) | — | |
| SCHEMBL2892531 | 0.93 | — | — | |
| SCHEMBL22563720 | 0.80 | — | — | |
| SCHEMBL1952601 | 0.77 | CXCR4 (0.32) | — | |
| SCHEMBL17641535 | 0.77 | — | — | |
| SCHEMBL3644949 | 0.76 | — | — | |
| SCHEMBL28931546 | 0.74 | FDPS (0.31) | — | |
| SCHEMBL28210285 | 0.74 | — | — | |
| SCHEMBL12160622 | 0.74 | RAD52 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118488982-A | Polyol catalyst for two-component polyurethane systems | 阿科玛法国公司 | 2024-08-13 | — | — | CN | claimed |
| CN-118488982-A | Polyol catalyst for two-component polyurethane systems | 阿科玛法国公司 | 2024-08-13 | — | — | CN | disclosed |
| US-8614330-B2 | Substituted benz-azoles and methods of their use as inhibitors of RAF kinase | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2013-12-24 | — | — | US | disclosed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120288501-A1 | SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. FORMERLY KNOWN AS CHIRON CORPORATION (US) | 2012-11-15 | — | — | US | disclosed |
| US-8299108-B2 | for treatment of hematological/hormone-dependent cancer | NOVARTIS AG (CH) | 2012-10-30 | — | — | US | disclosed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | disclosed |
| US-20100227856-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100196368-A1 | SUBSTITUTED BENZ-AZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-08-05 | — | — | US | disclosed |
| US-7728010-B2 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-6426337-B1 | ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-07-30 | — | — | US | disclosed |
| US-20020086850-A1 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives | COX BRIAN (GB) | 2002-07-04 | — | — | US | disclosed |
| WO-2001092232-A1 | 4-AMINOQUINOLINES AS ANTIINFECTIVE AGENTS | UFC LTD. (GB) | 2001-12-06 | — | — | WO | disclosed |
| CN-1246124-A | 2- (purin-9-YL) -tetrahydrofuran-3, 4-diol derivatives | GLAXO GROUP LTD (GB) | 2000-03-01 | — | — | CN | disclosed |
| EP-0948509-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998028319-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |
| EP-0187524-B1 | A DIARYL BUTYRIC ACID DERIVATIVE AND THE PRODUCTION PROCESS THEREOF | SUNTORY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4766116-A | NERVOUS SYSTEM DISORDERS | SUNTORY LIMITED (JP) | 1988-08-23 | — | — | US | disclosed |
| EP-0187524-A2 | A diaryl butyric acid derivative and the production process thereof | SUNTORY LIMITED (JP) | 1986-07-16 | — | — | EP | disclosed |
| US-4288592-A | Process for preparing amides by reaction in presence of molecular sieve | AMERICAN CYANAMID COMPANY (US) | 1981-09-08 | — | — | US | disclosed |