Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48648 | 0.89 | TSHR (0.32) | — | |
| SCHEMBL3316896 | 0.86 | CAMK2A (0.30) | CAMK2A | |
| Bicarbonate SCHEMBL1832825 | 0.83 | TSHR (0.35) | ACHE | |
| Ethylenediamine SCHEMBL28158413 | 0.81 | ALDH1A1 (0.37) | — | |
| SCHEMBL140261 | 0.80 | GAA (0.35) | GAAACHE | |
| SCHEMBL16618487 | 0.78 | GAA (0.39) | GPR84FFAR1FFAR4GAAACHE | |
| SCHEMBL9801718 | 0.78 | GAA (0.39) | GPR84FFAR1FFAR4GAAACHE | |
| SCHEMBL9801412 | 0.78 | GAA (0.39) | GPR84FFAR1FFAR4GAAACHE | |
| SCHEMBL16618645 | 0.78 | GAA (0.39) | GPR84FFAR1FFAR4GAAACHE | |
| SCHEMBL283579 | 0.78 | GAA (0.39) | GPR84FFAR1FFAR4GAAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112029134-B | Polyurethane composite foaming agent containing dialkyl carbonate and alkanolamine salt | 毕戈华 | 2023-01-24 | — | — | CN | disclosed |