Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28763802 | 0.87 | HDAC1 (0.56) | HDAC1HDAC2HDAC3MAPK1HDAC4 | |
| SCHEMBL28942997 | 0.86 | HDAC1 (0.58) | HDAC1HDAC2HDAC3PTGS1MAPK1 | |
| SCHEMBL29549466 | 0.80 | POLB (0.62) | HDAC1HDAC2HDAC3PTGS1MAPK1 | |
| SCHEMBL28763779 | 0.80 | POLB (0.62) | HDAC1HDAC2HDAC3PTGS1MAPK1 | |
| SCHEMBL29549870 | 0.77 | ALDH1A1 (0.61) | MEN1POLBKMT2ACA12 | |
| SCHEMBL28763787 | 0.77 | ALDH1A1 (0.61) | MEN1POLBKMT2ACA12 | |
| SCHEMBL4579192 | 0.75 | HDAC2 (0.55) | HDAC1HDAC2HDAC3NPSR1GPR55 | |
| SCHEMBL1063628 | 0.75 | HDAC1 (1.00) | HDAC1HDAC2HDAC3MAPK1HDAC4 | |
| SCHEMBL8401704 | 0.73 | HDAC1 (0.89) | HDAC1HDAC2HDAC3PTGS1MAPK1 | |
| SCHEMBL1065176 | 0.73 | HDAC1 (0.78) | HDAC1HDAC2HDAC3MAPK1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110452152-B | 1, 3-dioxo isoindoline benzamide compound and application thereof | 中国医学科学院药物研究所 | 2022-05-20 | — | — | CN | claimed |
| CN-110452152-B | 1, 3-dioxo isoindoline benzamide compound and application thereof | 中国医学科学院药物研究所 | 2022-05-20 | — | — | CN | disclosed |