Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.54 |
| ▸ | RXRB | P28702 | 5/20 | 0.54 |
| ▸ | RXRG | P48443 | 5/20 | 0.54 |
| ▸ | RARB | P10826 | 10/20 | 0.48 |
| ▸ | RARG | P13631 | 9/20 | 0.48 |
| ▸ | RARA | P10276 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596854 | 0.81 | CYP1A2 (0.37) | RXRARXRBRXRGRARBRARG | |
| Diethylamine SCHEMBL29140690 | 0.80 | CA12 (0.37) | RXRARXRBRXRGMEN1ESR1 | |
| Diethylamine SCHEMBL29140685 | 0.80 | RXRA (0.40) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6244149 | 0.70 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6904473 | 0.70 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7225318 | 0.69 | RARB (0.53) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL24055125 | 0.69 | RXRA (0.63) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL16914603 | 0.67 | RXRA (0.53) | RXRARXRBRXRGRARBRARG | |
| Bexarotene SCHEMBL9025 | 0.65 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| Bexarotene SCHEMBL5322954 | 0.65 | RXRA (1.00) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117986173-A | Prodrugs of retinoic acid and retinoid compounds | 于崇曦 | 2024-05-07 | — | — | CN | claimed |
| CN-113636966-B | Prodrugs of retinoic acid and retinoid compounds | 于崇曦 | 2024-01-12 | — | — | CN | claimed |
| CN-117986173-A | Prodrugs of retinoic acid and retinoid compounds | 于崇曦 | 2024-05-07 | — | — | CN | disclosed |
| CN-113636966-B | Prodrugs of retinoic acid and retinoid compounds | 于崇曦 | 2024-01-12 | — | — | CN | disclosed |
| CN-111714479-B | Pharmaceutical composition containing Bexarotene | 中国医学科学院药物研究所 | 2023-05-05 | — | — | CN | disclosed |
| CN-111956638-B | Application of Bexarotene or/and pharmaceutically acceptable salt thereof in preparation of anti-pulmonary hypertension drugs | 上海宛文创业孵化器管理合伙企业(有限合伙) | 2023-01-24 | — | — | CN | disclosed |
| CN-111956638-B | Application of Bexarotene or/and pharmaceutically acceptable salt thereof in preparation of anti-pulmonary hypertension drugs | 上海宛文创业孵化器管理合伙企业(有限合伙) | 2023-01-24 | — | — | CN | disclosed |