Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 1.00 |
| ▸ | CPT1A | P50416 | 3/20 | 0.54 |
| ▸ | CPT2 | P23786 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28943298 | 1.00 | TRPV1 (1.00) | TRPV1CPT1ACPT2THRBALOX12 | |
| SCHEMBL28943369 | 0.92 | TRPV1 (0.85) | TRPV1CPT1ACPT2POLBNPC1 | |
| SCHEMBL28943370 | 0.92 | TRPV1 (0.85) | TRPV1CPT1ACPT2POLBNPC1 | |
| SCHEMBL28943281 | 0.88 | TRPV1 (0.78) | TRPV1CPT1ACPT2KMT2APOLB | |
| SCHEMBL28943279 | 0.88 | TRPV1 (0.78) | TRPV1CPT1ACPT2KMT2APOLB | |
| SCHEMBL30212104 | 0.88 | TRPV1 (0.78) | TRPV1CPT1ACPT2KMT2APOLB | |
| SCHEMBL28943342 | 0.85 | TRPV1 (0.77) | TRPV1CPT1ACPT2HSD11B1CPT1B | |
| SCHEMBL28943345 | 0.85 | TRPV1 (0.77) | TRPV1CPT1ACPT2HSD11B1CPT1B | |
| SCHEMBL28943403 | 0.85 | TRPV1 (0.82) | TRPV1CPT1ACPT2KMT2APOLB | |
| SCHEMBL28943401 | 0.85 | TRPV1 (0.82) | TRPV1CPT1ACPT2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | claimed |
| CN-111423432-A | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-111423432-A | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-17 | — | — | CN | disclosed |