Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.78 |
| ▸ | CPT1A | P50416 | 5/20 | 0.46 |
| ▸ | CPT2 | P23786 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28943279 | 1.00 | TRPV1 (0.78) | TRPV1CPT1ACPT2POLBKDM4E | |
| SCHEMBL28943281 | 1.00 | TRPV1 (0.78) | TRPV1CPT1ACPT2POLBKDM4E | |
| SCHEMBL28943298 | 0.88 | TRPV1 (1.00) | TRPV1CPT1ACPT2POLBNPC1 | |
| SCHEMBL28943294 | 0.88 | TRPV1 (1.00) | TRPV1CPT1ACPT2POLBNPC1 | |
| SCHEMBL28943332 | 0.86 | TRPV1 (0.81) | TRPV1CPT1ACPT2POLBMEN1 | |
| SCHEMBL30212576 | 0.86 | TRPV1 (0.81) | TRPV1CPT1ACPT2POLBMEN1 | |
| SCHEMBL28943330 | 0.86 | TRPV1 (0.81) | TRPV1CPT1ACPT2POLBMEN1 | |
| SCHEMBL28943369 | 0.81 | TRPV1 (0.85) | TRPV1CPT1ACPT2POLBNPC1 | |
| SCHEMBL28943370 | 0.81 | TRPV1 (0.85) | TRPV1CPT1ACPT2POLBNPC1 | |
| SCHEMBL28943345 | 0.80 | TRPV1 (0.77) | TRPV1CPT1ACPT2CPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | claimed |
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | disclosed |