Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198668 | 0.75 | UGT2B7 (0.36) | LMNAUGT2B7ALOX12KDM4EHSD17B10 | |
| SCHEMBL28166206 | 0.71 | UGT2B7 (0.41) | LMNATRPA1PTGS1CACNA1CALDH1A1 | |
| SCHEMBL4832080 | 0.70 | UGT2B7 (0.52) | LMNATRPA1PTGS1CACNA1CALDH1A1 | |
| SCHEMBL181347 | 0.70 | UGT2B7 (0.58) | LMNATRPA1PTGS1CACNA1CALDH1A1 | |
| SCHEMBL30031337 | 0.70 | UGT2B7 (0.58) | LMNATRPA1PTGS1CACNA1CALDH1A1 | |
| SCHEMBL27802183 | 0.69 | — | — | |
| SCHEMBL27802215 | 0.69 | CYP2A6 (0.42) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| Water SCHEMBL10391367 | 0.68 | UGT2B7 (0.56) | LMNATRPA1PTGS1CACNA1CALDH1A1 | |
| Water SCHEMBL9862270 | 0.68 | UGT2B7 (0.56) | LMNATRPA1PTGS1CACNA1CALDH1A1 | |
| Water SCHEMBL9862280 | 0.68 | UGT2B7 (0.56) | LMNATRPA1PTGS1CACNA1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970396-B | Novel ruthenium complexes as catalysts for metathesis reactions | HOFFMANN LA ROCHE | 2014-06-18 | — | — | CN | claimed |
| EP-2276725-B1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS | HOFFMANN LA ROCHE (CH) | 2012-07-04 | — | — | EP | claimed |
| US-7939668-B2 | Ruthenium complexes as catalysts for metathesis reactions | ROCHE PALO ALTO LLC (US) | 2011-05-10 | — | — | US | claimed |
| CN-101970396-A | Novel ruthenium complexes as catalysts for metathesis reactions | HOFFMANN LA ROCHE | 2011-02-09 | — | — | CN | claimed |
| EP-2276725-A1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS | F. Hoffmann-La Roche AG (CH) | 2011-01-26 | — | — | EP | claimed |
| US-20090275714-A1 | New Ruthenium Complexes as Catalysts for Metathesis Reactions | ROCHE PALO ALTO LLC | 2009-11-05 | — | — | US | claimed |
| WO-2009124853-A1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-15 | — | — | WO | claimed |
| CN-102421786-B | The preparation method of ruthenium transposition composite catalyst | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-20 | — | — | CN | disclosed |
| CN-101970396-B | Novel ruthenium complexes as catalysts for metathesis reactions | HOFFMANN LA ROCHE | 2014-06-18 | — | — | CN | disclosed |
| EP-2427469-B1 | PROCESS FOR THE PREPARATION OF RUTHENIUM METATHESIS COMPLEX CATALYSTS | HOFFMANN LA ROCHE (CH) | 2013-12-11 | — | — | EP | disclosed |
| US-8288534-B2 | Process for the preparation a ruthenium complex | ROCHE PALO ALTO LLC (US) | 2012-10-16 | — | — | US | disclosed |
| EP-2276725-B1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS | HOFFMANN LA ROCHE (CH) | 2012-07-04 | — | — | EP | disclosed |
| CN-102421786-A | Process for the preparation of ruthenium metathesis complex catalysts | HOFFMANN LA ROCHE | 2012-04-18 | — | — | CN | disclosed |
| US-7939668-B2 | Ruthenium complexes as catalysts for metathesis reactions | ROCHE PALO ALTO LLC (US) | 2011-05-10 | — | — | US | disclosed |
| CN-101970396-A | Novel ruthenium complexes as catalysts for metathesis reactions | HOFFMANN LA ROCHE | 2011-02-09 | — | — | CN | disclosed |
| EP-2276725-A1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS | F. Hoffmann-La Roche AG (CH) | 2011-01-26 | — | — | EP | disclosed |
| WO-2010127964-A1 | PROCESS FOR THE PREPARATION OF RUTHENIUM METATHESIS COMPLEX CATALYSTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| US-20100286403-A1 | PROCESS FOR THE PREPARATION A RUTHENIUM COMPLEX | ROCHE PALO ALTO LLC | 2010-11-11 | — | — | US | disclosed |
| US-20090275714-A1 | New Ruthenium Complexes as Catalysts for Metathesis Reactions | ROCHE PALO ALTO LLC | 2009-11-05 | — | — | US | disclosed |
| WO-2009124853-A1 | NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286403-A1 | PROCESS FOR THE PREPARATION A RUTHENIUM COMPLEX | CYP3A4, CYP3A5, CYP3A7 | LMNA 4104/4885TRPA1 4572/4885PTGS1 1932/4885 |
| US-20090275714-A1 | New Ruthenium Complexes as Catalysts for Metathesis Reactions | HABP2, CYP3A7, ACE | LMNA 4647/4885TRPA1 4467/4885PTGS1 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.