Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637704 | 0.89 | ROCK2 (0.65) | ROCK2ROCK1 | |
| SCHEMBL29674785 | 0.78 | ROCK2 (0.76) | ROCK2ROCK1 | |
| SCHEMBL28777004 | 0.78 | ROCK2 (0.76) | ROCK2ROCK1 | |
| SCHEMBL24271321 | 0.75 | KCNH2 (0.35) | ROCK2ROCK1 | |
| SCHEMBL16637702 | 0.74 | ROCK2 (0.44) | ROCK2ROCK1 | |
| SCHEMBL28777011 | 0.72 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL28777015 | 0.72 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL29674607 | 0.72 | ROCK2 (0.42) | ROCK2ROCK1 | |
| SCHEMBL29674765 | 0.71 | MAP4K4 (0.38) | — | |
| SCHEMBL28777048 | 0.71 | LCK (0.45) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573566-B | Selective ROCK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-114573566-A | Selective ROCK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2022-06-03 | — | — | CN | disclosed |