Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398868 | 0.84 | METAP2 (0.44) | METAP2METAP1NPY5RENPP1GRIN2B | |
| SCHEMBL5440113 | 0.78 | KDM4C (0.47) | METAP2METAP1KDM4CNPY5RPDE5A | |
| SCHEMBL7626867 | 0.77 | METAP2 (0.39) | METAP2METAP1NPY5RENPP1PDE5A | |
| SCHEMBL1235369 | 0.77 | METAP2 (0.37) | METAP2METAP1NPY5RENPP1GRIN2B | |
| SCHEMBL1193887 | 0.76 | METAP2 (0.44) | METAP2METAP1NPY5RENPP1PDE5A | |
| SCHEMBL3179127 | 0.76 | METAP2 (0.41) | METAP2METAP1NPY5RENPP1GRIN2B | |
| SCHEMBL3480985 | 0.75 | METAP2 (0.38) | METAP2METAP1NPY5RENPP1PTGDR2 | |
| SCHEMBL852580 | 0.74 | METAP2 (0.43) | METAP2METAP1KDM4CNPY5RENPP1 | |
| SCHEMBL14125937 | 0.73 | KDM4E (0.46) | METAP2METAP1ENPP1PDE5AGRIN2B | |
| SCHEMBL375955 | 0.73 | SMN1; SMN2 (0.52) | METAP2METAP1NPY5RENPP1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152875-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | Sirna Therapeutics Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-2152870-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | Sirna Therapeutics Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-2152878-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | Sirna Therapeutics Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-2152877-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE ( PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | Sirna Therapeutics Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| EP-2152876-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | Sirna Therapeutics Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008137761-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137751-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137775-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137771-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE ( PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137776-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE (PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| EP-1987145-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS | Sirna Therapeutics Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007076328-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS | SIRNA THERAPEUTICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |