SCHEMBL28945875

SCHEMBL28945875

c1cc2c(s1)[C@H](CCCC[C@@H]1OCCc3ccsc31)OCC2

nearest known ligand 0.77

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 12/20 0.77
HTR1A P08908 1/20 0.65
DRD2 P14416 1/20 0.65
HTR7 P34969 1/20 0.65
KEAP1 Q14145 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28964100 0.98 TAAR1 (0.74) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL14903761 0.87 TAAR1 (1.00) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL2042943 0.87 TAAR1 (1.00) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL6551697 0.87 TAAR1 (0.72) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL14903760 0.84 TAAR1 (0.76) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL2037558 0.84 TAAR1 (0.76) TAAR1HTR1ADRD2HTR7KEAP1
Hydrochloric Acid SCHEMBL28514686 0.83 TAAR1 (0.74) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL14903730 0.83 TAAR1 (1.00) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL21282227 0.83 TAAR1 (0.71) TAAR1HTR1ADRD2HTR7KEAP1
SCHEMBL12644088 0.83 TAAR1 (1.00) TAAR1HTR1ADRD2HTR7KEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115677718-A Methylmethylamine derivative preparation, pharmaceutical composition and application thereof 武汉思瓴生物科技有限公司 2023-02-03 CN disclosed