Iodide

Iodide

SCHEMBL2894608

C=CCN1C=CN(CCCCCC)C1.I

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.30
TSHR P16473 2/20 0.36
GUSB P08236 2/20 0.33
EBP Q15125 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
NPC1 O15118 1/20 0.32
LMNA P02545 1/20 0.32
APOBEC3A P31941 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
NOD2 Q9HC29 1/20 0.32
ALDH1A1 P00352 2/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
PTGS1 P23219 3/20 0.31
PTGS2 P35354 3/20 0.31
MGLL Q99685 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2693560 0.98 TSHR (0.38) TSHRGUSBEBPSIGMAR1ALDH1A1
SCHEMBL15901603 0.98 TSHR (0.38) TSHRGUSBEBPSIGMAR1ALDH1A1
SCHEMBL4358564 0.98 TSHR (0.38) TSHRGUSBEBPSIGMAR1ALDH1A1
SCHEMBL3398654 0.98 TSHR (0.38) TSHRGUSBEBPSIGMAR1ALDH1A1
Hydrochloric Acid SCHEMBL2900817 0.97 TSHR (0.36) TSHRGUSBEBPSIGMAR1ALDH1A1
Bromide SCHEMBL4362539 0.97 TSHR (0.36) TSHRGUSBEBPSIGMAR1NPC1
Hydrochloric Acid SCHEMBL28380752 0.97 TSHR (0.36) TSHRGUSBEBPSIGMAR1ALDH1A1
Bromide SCHEMBL29249978 0.97 TSHR (0.36) TSHRGUSBEBPSIGMAR1NPC1
SCHEMBL1680335 0.96 TSHR (0.34) TSHRGUSBEBPSIGMAR1ALDH1A1
Bromide SCHEMBL4364815 0.95 TSHR (0.33) TSHRGUSBEBPSIGMAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101796058-B Curable and cured silicone rubber compositions and methods for their preparation using functionalised silica MOMENTIVE PERFORMANCE MAT INC 2014-05-21 CN disclosed
EP-2178889-B1 CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA MOMENTIVE PERFORMANCE MAT INC (US) 2013-10-02 EP disclosed
US-8501856-B2 Curable silicon-containing compositions possessing high translucency MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-08-06 US disclosed
CN-101796140-B Curable silicon-containing compositions possessing high translucency MOMENTIVE PERFORMANCE MAT INC 2013-07-17 CN disclosed
US-7790829-B2 Curable and cured silicone rubber compositions and methods therefor MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2010-09-07 US disclosed
CN-101796140-A Curable silicon-containing compositions possessing high translucency MOMENTIVE PERFORMANCE MAT INC 2010-08-04 CN disclosed
CN-101796058-A Use curable and solidified rubber composition of functional silicon dioxide and preparation method thereof MOMENTIVE PERFORMANCE MAT INC 2010-08-04 CN disclosed
EP-2178889-A1 CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA Momentive Performance Materials Inc. (US) 2010-04-28 EP disclosed
WO-2009011779-A1 CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-01-22 WO disclosed
US-20090018261-A1 Curable and cured silicone rubber compositions and methods therefor MOMENTIVE PERFORMANCE MATERIALS, INC. 2009-01-15 US disclosed
US-20090018260-A1 Curable silicon-containing compositions possessing high translucency MOMENTIVE PERFORMANCE MATERIALS INC. 2009-01-15 US disclosed