Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.33 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.31 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.31 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.30 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.33 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28380752 | 1.00 | TSHR (0.36) | TSHRGNAI3GNAO1GNAI1GUSB | |
| SCHEMBL15901603 | 0.98 | TSHR (0.38) | TSHRGNAI3GNAO1GNAI1GUSB | |
| Hydrochloric Acid SCHEMBL28958784 | 0.98 | TSHR (0.33) | TSHRGNAI3GNAO1GNAI1GUSB | |
| SCHEMBL2693560 | 0.98 | TSHR (0.38) | TSHRGNAI3GNAO1GNAI1GUSB | |
| SCHEMBL3398654 | 0.98 | TSHR (0.38) | TSHRGNAI3GNAO1GNAI1GUSB | |
| SCHEMBL4358564 | 0.98 | TSHR (0.38) | TSHRGNAI3GNAO1GNAI1GUSB | |
| Bromide SCHEMBL4362539 | 0.97 | TSHR (0.36) | TSHRGNAI3GNAO1GNAI1GUSB | |
| Bromide SCHEMBL29249978 | 0.97 | TSHR (0.36) | TSHRGNAI3GNAO1GNAI1GUSB | |
| Iodide SCHEMBL2894608 | 0.97 | TSHR (0.36) | TSHRGNAI3GNAO1GNAI1GUSB | |
| SCHEMBL1680335 | 0.96 | TSHR (0.34) | TSHRGUSBEBPSIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118272010-B | Aqueous iodine-fixing binder and preparation method and application thereof | 广东工业大学 | 2024-07-26 | — | — | CN | claimed |
| CN-118272010-A | Aqueous iodine-fixing binder and preparation method and application thereof | 广东工业大学 | 2024-07-02 | — | — | CN | claimed |
| CN-108179642-B | Preparation method of color fixing agent for reactive dye dyeing | 南通市武鑫化工有限公司 | 2020-11-13 | — | — | CN | claimed |
| CN-108049223-B | Color fixing agent for reactive dye dyeing and preparation method thereof | 台山市红岭洗染有限公司 | 2020-01-10 | — | — | CN | claimed |
| CN-119039622-A | Photoelectric dual-mode responsive photonic crystal hydrogel suitable for DLP three-dimensional molding | 浙江理工大学 | 2024-11-29 | — | — | CN | disclosed |
| CN-118272010-B | Aqueous iodine-fixing binder and preparation method and application thereof | 广东工业大学 | 2024-07-26 | — | — | CN | disclosed |
| CN-118272010-A | Aqueous iodine-fixing binder and preparation method and application thereof | 广东工业大学 | 2024-07-02 | — | — | CN | disclosed |
| CN-108179642-B | Preparation method of color fixing agent for reactive dye dyeing | 南通市武鑫化工有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-108049223-B | Color fixing agent for reactive dye dyeing and preparation method thereof | 台山市红岭洗染有限公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-2178889-B1 | CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA | MOMENTIVE PERFORMANCE MAT INC (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8501856-B2 | Curable silicon-containing compositions possessing high translucency | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-7790829-B2 | Curable and cured silicone rubber compositions and methods therefor | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090018260-A1 | Curable silicon-containing compositions possessing high translucency | MOMENTIVE PERFORMANCE MATERIALS INC. | 2009-01-15 | — | — | US | disclosed |
| US-20090018261-A1 | Curable and cured silicone rubber compositions and methods therefor | MOMENTIVE PERFORMANCE MATERIALS, INC. | 2009-01-15 | — | — | US | disclosed |