Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK3 | Q16288 | 19/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 18/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 18/20 | 1.00 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28505742 | 0.84 | NTRK3 (0.73) | NTRK3NTRK1NTRK2 | |
| SCHEMBL28501624 | 0.83 | NTRK3 (0.71) | NTRK3NTRK1NTRK2 | |
| SCHEMBL28511513 | 0.81 | NTRK3 (0.68) | NTRK3NTRK1NTRK2RET | |
| SCHEMBL28514347 | 0.80 | NTRK3 (1.00) | NTRK3NTRK1NTRK2RET | |
| SCHEMBL28505375 | 0.78 | NTRK3 (0.65) | NTRK3NTRK1NTRK2 | |
| SCHEMBL28505374 | 0.78 | NTRK3 (0.71) | NTRK3NTRK1NTRK2 | |
| SCHEMBL28503859 | 0.77 | NTRK3 (0.63) | NTRK3NTRK1NTRK2RET | |
| SCHEMBL28511507 | 0.73 | NTRK3 (0.85) | NTRK3NTRK1NTRK2RET | |
| SCHEMBL30492102 | 0.73 | NTRK3 (0.57) | NTRK3NTRK1NTRK2 | |
| SCHEMBL28502718 | 0.72 | NTRK1 (0.80) | NTRK3NTRK1NTRK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112225748-B | Small molecule compound with FLT3 kinase inhibitory activity and application thereof | 四川大学华西医院 | 2021-11-30 | — | — | CN | disclosed |
| CN-112225748-A | Small molecule compound with FLT3 kinase inhibitory activity and application thereof | 四川大学华西医院 | 2021-01-15 | — | — | CN | disclosed |