Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK3 | Q16288 | 10/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 9/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 9/20 | 1.00 |
| ▸ | RET | P07949 | 10/20 | 0.67 |
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | HCK | P08631 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | CDK4 | P11802 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.65 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511507 | 0.92 | NTRK3 (0.85) | NTRK3NTRK1NTRK2RETBRAF | |
| SCHEMBL28503848 | 0.89 | NTRK1 (0.80) | NTRK3NTRK1NTRK2RETBRAF | |
| SCHEMBL28502718 | 0.89 | NTRK1 (0.80) | NTRK3NTRK1NTRK2RETFRK | |
| SCHEMBL28501624 | 0.83 | NTRK3 (0.71) | NTRK3NTRK1NTRK2FRKMERTK | |
| SCHEMBL28960370 | 0.80 | NTRK3 (1.00) | NTRK3NTRK1NTRK2RET | |
| SCHEMBL28505742 | 0.80 | NTRK3 (0.73) | NTRK3NTRK1NTRK2FRKMERTK | |
| SCHEMBL28511513 | 0.79 | NTRK3 (0.68) | NTRK3NTRK1NTRK2RET | |
| SCHEMBL13234898 | 0.78 | NTRK1 (0.64) | NTRK3NTRK1NTRK2RETBRAF | |
| SCHEMBL28505375 | 0.76 | NTRK3 (0.65) | NTRK3NTRK1NTRK2FRKMERTK | |
| SCHEMBL3762933 | 0.76 | NTRK1 (0.61) | NTRK3NTRK1NTRK2RETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116410203-B | Compound with TRK and drug-resistant mutation inhibition activity and application thereof | 四川大学 | 2024-06-25 | — | — | CN | disclosed |
| CN-116410203-A | Compound with TRK and drug-resistant mutation inhibition activity and application thereof | 四川大学 | 2023-07-11 | — | — | CN | disclosed |
| CN-112225748-B | Small molecule compound with FLT3 kinase inhibitory activity and application thereof | 四川大学华西医院 | 2021-11-30 | — | — | CN | disclosed |
| CN-112225748-A | Small molecule compound with FLT3 kinase inhibitory activity and application thereof | 四川大学华西医院 | 2021-01-15 | — | — | CN | disclosed |