Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 8/20 | 0.58 |
| ▸ | GPR183 | P32249 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896347 | 1.00 | CCR2 (0.58) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2904879 | 0.95 | CCR2 (0.56) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2903823 | 0.95 | CCR2 (0.56) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2903826 | 0.95 | CCR2 (0.56) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2904880 | 0.95 | CCR2 (0.56) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL1587699 | 0.89 | CCR2 (0.52) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL1587696 | 0.89 | CCR2 (0.52) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2903235 | 0.89 | CCR2 (0.51) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2903391 | 0.88 | NPC1 (0.57) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2903396 | 0.88 | NPC1 (0.57) | CCR2GPR183NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |