Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pivalate SCHEMBL7193606 | 0.85 | TSHR (0.32) | ALDH1A1TSHR | |
| SCHEMBL52209 | 0.85 | — | — | |
| SCHEMBL27741207 | 0.82 | — | — | |
| Water SCHEMBL28304970 | 0.82 | — | — | |
| Propene SCHEMBL9248767 | 0.79 | — | — | |
| Acetone SCHEMBL6848117 | 0.77 | HPGD (0.31) | HPGD | |
| SCHEMBL7747591 | 0.76 | GRIK1 (0.32) | — | |
| SCHEMBL5857687 | 0.75 | KDM4E (0.30) | — | |
| Hexane SCHEMBL10669546 | 0.72 | TSHR (0.48) | LMNAALDH1A1TSHR | |
| SCHEMBL16912963 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109416414-B | Increased hardness central optic zone in soft contact lenses for astigmatism correction | 庄臣及庄臣视力保护公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-109563293-B | Polymer compositions containing grafted polymer networks and methods for making and using the same | 庄臣及庄臣视力保护公司 | 2022-06-03 | — | — | CN | disclosed |