Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888850 | 0.87 | ESR2 (0.41) | GPR119ESR2NR1H2FAAHCHEK2 | |
| SCHEMBL2890933 | 0.87 | ESR2 (0.42) | GPR119ESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2889302 | 0.86 | ESR2 (0.42) | GPR119ESR2NR1H2MAPK1 | |
| SCHEMBL2887295 | 0.85 | ESR2 (0.44) | GPR119ESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2890958 | 0.83 | GPR119 (0.44) | GPR119ESR2NR1H2MAPK1 | |
| SCHEMBL2886944 | 0.82 | ACACB (0.42) | GPR119ESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2883177 | 0.82 | ESR2 (0.40) | GPR119ESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2883210 | 0.82 | ESR2 (0.40) | GPR119ESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2888755 | 0.81 | ESR2 (0.39) | GPR119ESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2889110 | 0.81 | ESR2 (0.40) | GPR119ESR2NR1H2MAPK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213675-A1 | PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-08-04 | — | — | EP | disclosed |