SCHEMBL28966397

SCHEMBL28966397

Cc1cc(I)nn1COCC[Si](C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 3/20 0.34
PDE10A Q9Y233 2/20 0.32
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29632252 0.83 KDM4E (0.46)
SCHEMBL28433465 0.83 DGAT1 (0.38) DGAT1NPC1
SCHEMBL28746975 0.83 DGAT1 (0.34) DGAT1NPC1
SCHEMBL28999311 0.81 DGAT1 (0.35) DGAT1
SCHEMBL401891 0.81 DGAT1 (0.34) DGAT1PDE10ANPC1
SCHEMBL15656304 0.81 DGAT1 (0.39) DGAT1PDE10ANPC1
SCHEMBL25179891 0.79 DGAT1 (0.34) DGAT1PDE10ANPC1
SCHEMBL25183328 0.79 POLB (0.35) DGAT1PDE10ANPC1
SCHEMBL31465949 0.79 DGAT1 (0.32) DGAT1
SCHEMBL31201796 0.77 F2RL1 (0.33) DGAT1PDE10ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768764-A Fused ring compound with anti-tumor activity and application thereof 上海翊石医药科技有限公司 2023-03-07 CN disclosed