⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2902386 | 0.98 | — | — | |
| SCHEMBL9701437 | 0.78 | GABRA1 (0.31) | — | |
| SCHEMBL16659921 | 0.78 | — | — | |
| SCHEMBL4480811 | 0.78 | — | — | |
| SCHEMBL12141649 | 0.78 | — | — | |
| SCHEMBL5158354 | 0.78 | — | — | |
| SCHEMBL5747179 | 0.76 | — | — | |
| SCHEMBL5747174 | 0.76 | — | — | |
| SCHEMBL16926354 | 0.76 | — | — | |
| SCHEMBL5747183 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | claimed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | claimed |
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | claimed |
| CN-110963959-B | Preparation method for synthesizing N-protected and unprotected 3-hydroxy-4, 4-dimethylpiperidine | 南京药石科技股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-110963959-B | Preparation method for synthesizing N-protected and unprotected 3-hydroxy-4, 4-dimethylpiperidine | 南京药石科技股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-110963959-B | Preparation method for synthesizing N-protected and unprotected 3-hydroxy-4, 4-dimethylpiperidine | 南京药石科技股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-110963959-A | Preparation method for synthesizing N-protected and unprotected 3-hydroxy-4, 4-dimethylpiperidine | 南京药石科技股份有限公司 | 2020-04-07 | — | — | CN | disclosed |
| CN-110963959-A | Preparation method for synthesizing N-protected and unprotected 3-hydroxy-4, 4-dimethylpiperidine | 南京药石科技股份有限公司 | 2020-04-07 | — | — | CN | disclosed |
| CN-110963959-A | Preparation method for synthesizing N-protected and unprotected 3-hydroxy-4, 4-dimethylpiperidine | 南京药石科技股份有限公司 | 2020-04-07 | — | — | CN | disclosed |
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| EP-2796456-A1 | Bicyclic compounds as Pim inhibitors | Amgen Inc. (US) | 2014-10-29 | — | — | EP | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |