Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28969017 | 1.00 | MDM4 (0.52) | MDM4TP53MDM2MMETLR2 | |
| SCHEMBL30306804 | 0.89 | MDM4 (0.42) | MDM4TP53MDM2MAPTL3MBTL1 | |
| SCHEMBL31524007 | 0.82 | MDM4 (0.55) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL28969035 | 0.82 | MDM4 (0.46) | MDM4TP53MDM2NPC1RAB9A | |
| SCHEMBL28969036 | 0.82 | MDM4 (0.46) | MDM4TP53MDM2NPC1RAB9A | |
| SCHEMBL31524119 | 0.81 | MDM4 (0.54) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL28969022 | 0.81 | MDM4 (0.50) | MDM4TP53MDM2TLR2CASP3 | |
| SCHEMBL28969021 | 0.81 | MDM4 (0.50) | MDM4TP53MDM2TLR2CASP3 | |
| SCHEMBL27041482 | 0.76 | SLC7A5 (0.50) | MDM4TP53MDM2CASP3 | |
| SCHEMBL27041478 | 0.76 | SLC7A5 (0.50) | MDM4TP53MDM2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4171547-A1 | TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Axial Therapeutics, Inc. (US) | 2023-05-03 | — | — | EP | disclosed |
| CN-115666553-A | TLR2 modulator compounds, and pharmaceutical compositions and uses thereof | 轴向治疗公司 | 2023-01-31 | — | — | CN | disclosed |