Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.49 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28969022 | 1.00 | MDM4 (0.50) | MDM4TP53MDM2TLR2CASP3 | |
| SCHEMBL30306827 | 0.89 | MDM4 (0.41) | MDM4TP53MDM2TLR2CASP3 | |
| SCHEMBL28969018 | 0.82 | CSNK2A2 (0.49) | MDM4TP53MDM2CASP3 | |
| SCHEMBL28969020 | 0.82 | CSNK2A2 (0.49) | MDM4TP53MDM2CASP3 | |
| SCHEMBL28969016 | 0.81 | MDM4 (0.52) | MDM4TP53MDM2TLR2CASP3 | |
| SCHEMBL28969017 | 0.81 | MDM4 (0.52) | MDM4TP53MDM2TLR2CASP3 | |
| SCHEMBL27041478 | 0.78 | SLC7A5 (0.50) | MDM4TP53MDM2CASP3TNF | |
| SCHEMBL27041482 | 0.78 | SLC7A5 (0.50) | MDM4TP53MDM2CASP3TNF | |
| SCHEMBL1768605 | 0.78 | PTPN1 (0.51) | MDM2TNF | |
| SCHEMBL1768601 | 0.78 | PTPN1 (0.51) | MDM2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4171547-A1 | TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Axial Therapeutics, Inc. (US) | 2023-05-03 | — | — | EP | disclosed |
| CN-115666553-A | TLR2 modulator compounds, and pharmaceutical compositions and uses thereof | 轴向治疗公司 | 2023-01-31 | — | — | CN | disclosed |