Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.52 |
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.48 |
| ▸ | INSR | P06213 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30001806 | 1.00 | LRRK2 (0.54) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL24752696 | 0.92 | MAP4K1 (0.63) | LRRK2MAP4K1MAPK3PTK2JAK2 | |
| SCHEMBL30002872 | 0.91 | MAPK3 (0.58) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL24752277 | 0.91 | MAPK3 (0.58) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL28969633 | 0.91 | MAP4K1 (0.54) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL30002296 | 0.91 | MAP4K1 (0.54) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL28969572 | 0.90 | LRRK2 (0.54) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL30002231 | 0.90 | LRRK2 (0.54) | LRRK2MAP4K1MAPK3PTK2ULK1 | |
| SCHEMBL28969606 | 0.87 | MAPK3 (0.61) | MAP4K1MAPK3PTK2JAK2NTRK1 | |
| SCHEMBL30002408 | 0.87 | MAPK3 (0.61) | MAP4K1MAPK3PTK2JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |