Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290105 | 0.88 | KDM4E (0.53) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL289832 | 0.87 | KDM4E (0.49) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL289679 | 0.85 | KDM4E (0.53) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL290387 | 0.85 | KDM4E (0.47) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL290238 | 0.84 | SMN1; SMN2 (0.56) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL289699 | 0.78 | KDM4E (0.61) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL26500225 | 0.76 | HDAC6 (0.36) | KDM4ERAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL289881 | 0.76 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL289408 | 0.74 | SMN1; SMN2 (0.72) | KDM4ESMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL289509 | 0.74 | KDM4E (0.55) | KDM4ESMN1; SMN2RAB9AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |