Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | XDH | P47989 | 3/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289832 | 0.89 | KDM4E (0.49) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289698 | 0.88 | KDM4E (0.48) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL290387 | 0.87 | KDM4E (0.47) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL290238 | 0.86 | SMN1; SMN2 (0.56) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289509 | 0.85 | KDM4E (0.55) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289699 | 0.80 | KDM4E (0.61) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL290134 | 0.79 | KDM4E (0.75) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289881 | 0.78 | SMN1; SMN2 (0.61) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL12712043 | 0.76 | CYP2A6 (0.41) | RAB9ASMN1; SMN2NPC1KMT2AALDH1A1 | |
| SCHEMBL289408 | 0.76 | SMN1; SMN2 (0.72) | KDM4ERAB9AGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |