Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 4/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060575 | 1.00 | NPC1 (0.32) | NPC1RAB9AMEN1HTTKMT2A | |
| SCHEMBL24781343 | 1.00 | NPC1 (0.32) | NPC1RAB9AMEN1HTTKMT2A | |
| SCHEMBL30062444 | 1.00 | NPC1 (0.32) | NPC1RAB9AMEN1HTTKMT2A | |
| SCHEMBL24781183 | 1.00 | NPC1 (0.32) | NPC1RAB9AMEN1HTTKMT2A | |
| SCHEMBL18942818 | 0.78 | LCK (0.34) | NPC1RAB9AMEN1KMT2AGHSR | |
| SCHEMBL31730656 | 0.77 | BACE1 (0.41) | NPC1RAB9ABACE1RECQLSMN1; SMN2 | |
| SCHEMBL4513886 | 0.77 | HDAC4 (0.33) | RORCAPLNR | |
| SCHEMBL4835508 | 0.74 | DPP8 (0.39) | BACE1RORCAPLNRGHSR | |
| SCHEMBL4835493 | 0.74 | DPP8 (0.39) | BACE1RORCAPLNRGHSR | |
| SCHEMBL306307 | 0.73 | GHSR (0.43) | NPC1RAB9AMEN1KMT2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485275-A | Compounds and compositions that inhibit HIF 2-alpha activity and methods of use thereof | 诺华股份有限公司 | 2022-12-16 | — | — | CN | disclosed |