Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochlorthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL27304280 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL27521171 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL28060281 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL450348 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL6291 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL3110285 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL9336266 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL2221733 | 0.80 | — | — | |
| Hydrochlorthiazide SCHEMBL2807097 | 0.80 | — | — | |
| Hydrochlorthiazide SCHEMBL11030364 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6025196-A | — | — | None | — | — | JP | disclosed |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2024-05-23 | — | — | US | disclosed |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2024-02-13 | — | — | US | disclosed |
| CN-114591991-A | Method for preparing calcipotriol key chiral intermediate based on short-chain carbonyl reductase | 西南交通大学 | 2022-06-07 | — | — | CN | disclosed |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-06-03 | — | — | US | disclosed |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-03-09 | — | — | US | disclosed |
| EP-3273793-B1 | AMINO ACID ANIMAL FEED COMPOSITION | BENEMILK OY (FI) | 2020-08-19 | — | — | EP | disclosed |
| CN-111225686-A | Treatment of inflammatory diseases using ingestible devices to release immunomodulators | 普罗根尼蒂公司 | 2020-06-02 | — | — | CN | disclosed |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2019-10-31 | — | — | US | disclosed |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2019-07-16 | — | — | US | disclosed |
| US-6833459-B2 | Reducing thiazole ester to thiazole alcohol using sodium borohydride in the presence of aluminum chloride in a solvent and oxidising the thiazole alcohol to obtain 4-methyl-5-formyl-thiazole | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2004-12-21 | — | — | US | disclosed |
| US-20040102493-A1 | Thia-and oxazoles and their use as ppars activators | SMITHKLINE BEECHAM CORPORATION | 2004-05-27 | — | — | US | disclosed |
| WO-2003091230-A1 | PROCESS FOR THE PREPARATION OF 4-METHYL-THIAZOLE-5-CARBALDEHYDE INTERMEDIATE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-11-06 | — | — | WO | disclosed |
| US-20030204095-A1 | Process for the preparation of thiazole intermediate | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-10-30 | — | — | US | disclosed |
| EP-1343772-A1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | disclosed |
| EP-1224316-A2 | 13-ALKYL EPOTHILONE DERIVATIVES | Novartis AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2002050048-A1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
| CN-1355807-A | Thiazoloindolinone compounds | GLAXO GROUP LTD (GB) | 2002-06-26 | — | — | CN | disclosed |
| WO-2001027308-A2 | 13-ALKYL EPOTHILONE DERIVATIVES | NOVARTIS AG (CH) | 2001-04-19 | — | — | WO | disclosed |
| JP-H0625196-A | PYRETHRINOID ESTERS DERIVED FROM THIAZOLE ALCOHOLS, THEIR PREPARATION AND THEIR USE AS PESTICIDES | ROUSSEL UCLAF | 1994-02-01 | — | — | JP | disclosed |