Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.76 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.76 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.76 |
| ▸ | MLNR | O43193 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.76 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.76 |
| ▸ | DRD2 | P14416 | 1/20 | 0.76 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.76 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.76 |
| ▸ | CNR1 | P21554 | 1/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.76 |
| ▸ | NPY1R | P25929 | 1/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL22324606 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Otilonium SCHEMBL109554 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22323721 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22323864 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22324633 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22323711 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22324597 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22324509 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL22324511 | 0.86 | NR1I2 (1.00) | MLNRNR1I2NR3C1PGRADRB2 | |
| Bromide SCHEMBL28300666 | 0.86 | ALDH1A1 (0.62) | MLNRNR1I2NR3C1PGRADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677525-A | Preparation method of otilonimide | 四平欧凯科技有限公司 | 2023-02-03 | — | — | CN | disclosed |