SCHEMBL28973151

SCHEMBL28973151

CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1[C@H]1CC[C@H](OCCBr)CC1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 14/20 0.57
HDAC1 Q13547 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28973154 1.00 AR (0.57) ARHDAC1
SCHEMBL28973134 0.95 AR (0.55) ARHDAC1
SCHEMBL28973137 0.95 AR (0.55) ARHDAC1
SCHEMBL28973186 0.92 AR (0.57) ARHDAC1
SCHEMBL28973191 0.92 AR (0.57) ARHDAC1
SCHEMBL28973185 0.90 AR (0.55) ARHDAC1
SCHEMBL28973189 0.90 AR (0.55) ARHDAC1
SCHEMBL17947697 0.90 AR (0.54) ARHDAC1
SCHEMBL28984100 0.87 AR (0.52) ARHDAC1
SCHEMBL30390169 0.87 AR (0.48) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115968293-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-04-14 CN disclosed
CN-115955979-A Cereblan binding compounds, compositions thereof, and methods for treatment thereof 新基公司 2023-04-11 CN disclosed
CN-115835866-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-03-21 CN disclosed