Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | APOL1 | O14791 | 11/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28863441 | 0.79 | APOL1 (0.49) | APOL1 | |
| SCHEMBL28974976 | 0.77 | APOL1 (0.45) | APOL1 | |
| SCHEMBL28974913 | 0.76 | APOL1 (0.40) | APOL1 | |
| SCHEMBL30218293 | 0.73 | AKR1C3 (0.39) | APPAKR1C3AKR1C2 | |
| SCHEMBL24098972 | 0.70 | GPR17 (0.50) | APOL1 | |
| SCHEMBL28974900 | 0.70 | FFAR1 (0.40) | APOL1 | |
| SCHEMBL28974800 | 0.69 | APOL1 (0.43) | APOL1 | |
| SCHEMBL28974884 | 0.68 | GPR17 (0.43) | APOL1 | |
| SCHEMBL28974886 | 0.68 | APOL1 (0.35) | APOL1 | |
| SCHEMBL29956407 | 0.68 | KDM4E (0.37) | APOL1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867532-A | Inhibitors of APOL1 and uses thereof | 弗特克斯药品有限公司 | 2023-03-28 | — | — | CN | disclosed |