Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 9/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28977180 | 0.88 | MELK (0.64) | MELKPRKD1HTR6MAP4K1FLT1 | |
| SCHEMBL28977160 | 0.88 | MELK (0.57) | MELKPRKD1MAP4K1CTSSCTSK | |
| SCHEMBL28977164 | 0.87 | MELK (0.65) | MELKPRKD1HTR6MAP4K1FLT1 | |
| SCHEMBL28977194 | 0.85 | MAP4K1 (0.61) | MELKPRKD1MAP4K1 | |
| SCHEMBL28977181 | 0.83 | MELK (0.73) | MELKPRKD1MAP4K1FLT1KDR | |
| SCHEMBL28977166 | 0.81 | MELK (0.65) | MELKPRKD1HTR6MAP4K1FLT1 | |
| SCHEMBL28687893 | 0.80 | MAP4K1 (0.57) | HTR6MAP4K1ALK | |
| SCHEMBL30290614 | 0.80 | MAP4K1 (0.57) | HTR6MAP4K1ALK | |
| SCHEMBL28977172 | 0.75 | MELK (0.86) | MELKPRKD1MAP4K1KDRFLT3 | |
| SCHEMBL28977189 | 0.75 | MELK (0.73) | MELKPRKD1MAP4K1KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861188-B | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2023-02-28 | — | — | CN | disclosed |