Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.73 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.62 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 9/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28977166 | 0.86 | MELK (0.65) | MELKMAP4K1PRMT5ALKPRKD1 | |
| SCHEMBL28977164 | 0.86 | MELK (0.65) | MELKMAP4K1PRMT5ALKPRKD1 | |
| SCHEMBL28977167 | 0.86 | MELK (0.70) | MELKMAP4K1PRKD1FLT3KDR | |
| SCHEMBL28977180 | 0.85 | MELK (0.64) | MELKMAP4K1PRMT5ALKPRKD1 | |
| SCHEMBL28977192 | 0.83 | MELK (0.66) | MELKMAP4K1PRKD1NPC1TP53 | |
| SCHEMBL28977161 | 0.83 | MELK (0.60) | MELKMAP4K1ALKPRKD1FLT3 | |
| SCHEMBL13202898 | 0.82 | RAB9A (0.67) | MAP4K1PRMT5ALKNPC1TP53 | |
| SCHEMBL28977159 | 0.79 | MELK (0.82) | MELKMAP4K1PRKD1FLT3KDR | |
| SCHEMBL28977165 | 0.79 | MELK (0.70) | MELKMAP4K1PRKD1FLT3FLT1 | |
| SCHEMBL28977172 | 0.79 | MELK (0.86) | MELKMAP4K1ALKPRKD1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861188-B | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2023-02-28 | — | — | CN | disclosed |