Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.54 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.54 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.54 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1409520 | 1.00 | MTOR (0.56) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL21029901 | 1.00 | MTOR (0.56) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL29727937 | 1.00 | MTOR (0.56) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL19629401 | 0.92 | MTOR (0.53) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL21029958 | 0.92 | MTOR (0.53) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL20692837 | 0.92 | MTOR (0.53) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL21394004 | 0.92 | MTOR (0.53) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL10124249 | 0.89 | MTOR (0.50) | MTORPIK3CAPIK3R1 | |
| SCHEMBL14811270 | 0.89 | MTOR (0.50) | MTORPIK3CAPIK3R1 | |
| SCHEMBL14811271 | 0.89 | MTOR (0.50) | MTORPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116102545-B | Diaryl urea PI3K/mTOR/HDAC multi-target inhibitor, and pharmaceutical composition and application thereof | 贵州医科大学 | 2025-03-25 | — | — | CN | disclosed |
| CN-114751899-B | Diaryl urea mTOR kinase inhibitor, and pharmaceutical composition and application thereof | 贵州医科大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-116102545-A | Diaryl urea PI3K/mTOR/HDAC multi-target inhibitor, and pharmaceutical composition and application thereof | 贵州医科大学 | 2023-05-12 | — | — | CN | disclosed |
| CN-114751899-A | Diaryl urea mTOR kinase inhibitor and pharmaceutical composition and application thereof | 贵州医科大学 | 2022-07-15 | — | — | CN | disclosed |