Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | CA2 | P00918 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30485097 | 0.95 | TDP1 (0.77) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL17377996 | 0.93 | TDP1 (0.74) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL19646831 | 0.89 | TDP1 (0.62) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL13247413 | 0.89 | MAOA (0.63) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL321315 | 0.89 | TDP1 (0.85) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL631719 | 0.89 | TDP1 (0.60) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL9998912 | 0.89 | TDP1 (0.60) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL20801639 | 0.89 | TDP1 (0.60) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL23288621 | 0.88 | TDP1 (0.83) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL27860437 | 0.87 | TDP1 (0.82) | TDP1MAOAMAOBMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115925721-A | Pyrimidone tricyclic derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2023-04-07 | — | — | CN | disclosed |