SCHEMBL28980671

SCHEMBL28980671

CS(=O)(=O)c1cn(-c2cc(F)cc(Cl)c2)c2c1[C@@H](O)C(F)(F)CC2

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
EPAS1 Q99814 16/20 0.53
ARNT P27540 9/20 0.53
VEGFA P15692 6/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24110081 1.00 EPAS1 (0.53) EPAS1ARNTVEGFA
SCHEMBL29116096 1.00 EPAS1 (0.53) EPAS1ARNTVEGFA
SCHEMBL24109744 0.93 EPAS1 (0.50) EPAS1ARNTVEGFA
SCHEMBL30936288 0.87 EPAS1 (0.43) EPAS1ARNTVEGFA
SCHEMBL25185350 0.87 EPAS1 (0.43) EPAS1ARNTVEGFA
SCHEMBL24110078 0.85 EPAS1 (0.56) EPAS1ARNTVEGFA
SCHEMBL30326113 0.85 EPAS1 (0.56) EPAS1ARNTVEGFA
SCHEMBL24109436 0.85 EPAS1 (0.45) EPAS1ARNTVEGFA
SCHEMBL30449307 0.85 EPAS1 (0.45) EPAS1ARNTVEGFA
SCHEMBL24110079 0.85 EPAS1 (0.44) EPAS1ARNTVEGFA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118119601-A Bicyclic compounds and uses thereof 贝达药业股份有限公司 2024-05-31 CN claimed
CN-115884966-A Bicyclic compounds and uses thereof 贝达药业股份有限公司 2023-03-31 CN claimed
CN-118119601-A Bicyclic compounds and uses thereof 贝达药业股份有限公司 2024-05-31 CN disclosed
CN-117126097-A Bicyclic compounds and uses thereof 贝达药业股份有限公司 2023-11-28 CN disclosed
CN-115884966-A Bicyclic compounds and uses thereof 贝达药业股份有限公司 2023-03-31 CN disclosed