Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.71 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.71 |
| ▸ | EGFR | P00533 | 5/20 | 0.64 |
| ▸ | FLT3 | P36888 | 3/20 | 0.64 |
| ▸ | BLK | P51451 | 3/20 | 0.64 |
| ▸ | SRC | P12931 | 7/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.62 |
| ▸ | BTK | Q06187 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | BMX | P51813 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28980977 | 0.90 | SRC (0.79) | MAP3K7MAPK1MAP2K1FLT3SRC | |
| SCHEMBL28980965 | 0.87 | MAP3K7 (0.81) | MAP3K7MAPK1MAP2K1EGFRFLT3 | |
| SCHEMBL28980990 | 0.87 | SRC (0.69) | MAP3K7MAPK1MAP2K1EGFRFLT3 | |
| SCHEMBL28980992 | 0.87 | BRD4 (0.72) | MAP3K7MAPK1MAP2K1EGFRFLT3 | |
| SCHEMBL28980966 | 0.86 | MAP3K7 (0.71) | MAP3K7MAPK1MAP2K1FLT3SRC | |
| SCHEMBL16391082 | 0.83 | EGFR (0.66) | EGFRSRCJAK3BTK | |
| SCHEMBL16372156 | 0.83 | EGFR (0.81) | MAP3K7MAPK1MAP2K1EGFRFLT3 | |
| SCHEMBL30672758 | 0.83 | EGFR (0.81) | MAP3K7MAPK1MAP2K1EGFRFLT3 | |
| SCHEMBL16706316 | 0.81 | JAK3 (0.68) | EGFRJAK3BTKJAK2 | |
| SCHEMBL15130594 | 0.81 | MAP3K7 (0.61) | MAP3K7MAPK1MAP2K1EGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4617261-A1 | 2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Wenzhou Medical University (CN) | 2025-09-17 | — | — | EP | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |