Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.69 |
| ▸ | EGFR | P00533 | 3/20 | 0.69 |
| ▸ | ITK | Q08881 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.68 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | BLK | P51451 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.67 |
| ▸ | BRD4 | O60885 | 10/20 | 0.66 |
| ▸ | BTK | Q06187 | 1/20 | 0.63 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684788 | 0.93 | BRD4 (0.78) | SRCEGFRITKBRD4BTK | |
| SCHEMBL18371448 | 0.93 | BRD4 (0.78) | SRCEGFRITKBRD4BTK | |
| SCHEMBL28980965 | 0.90 | MAP3K7 (0.81) | SRCEGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL22807490 | 0.90 | SRC (0.83) | SRCMAP3K7MAPK1MAP2K1FLT3 | |
| SCHEMBL28980992 | 0.89 | BRD4 (0.72) | SRCEGFRITKMAP3K7MAPK1 | |
| SCHEMBL28980985 | 0.87 | MAP3K7 (0.71) | SRCEGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL31684790 | 0.87 | MAP3K7 (0.70) | SRCMAP3K7MAPK1MAP2K1FLT3 | |
| SCHEMBL28980988 | 0.87 | MAP3K7 (0.70) | SRCMAP3K7MAPK1MAP2K1FLT3 | |
| SCHEMBL13169822 | 0.87 | MAP3K7 (0.62) | SRCEGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL31163110 | 0.87 | BRD4 (0.79) | FLT3BRD4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4617261-A1 | 2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Wenzhou Medical University (CN) | 2025-09-17 | — | — | EP | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |