Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 12/20 | 0.69 |
| ▸ | CDK6 | Q00534 | 12/20 | 0.69 |
| ▸ | CCNK | O75909 | 11/20 | 0.69 |
| ▸ | CDK9 | P50750 | 11/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.68 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.63 |
| ▸ | CDK2 | P24941 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CTSC | P53634 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684756 | 1.00 | CCND3 (0.69) | CCND3CDK6CCNKCDK9CYP3A4 | |
| SCHEMBL31684777 | 0.91 | MAP3K7 (0.80) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL28980982 | 0.91 | MAP3K7 (0.80) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL28980998 | 0.88 | MAP3K7 (0.73) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL31684766 | 0.88 | MAP3K7 (0.73) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL31684785 | 0.85 | MAP3K7 (0.66) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL28980978 | 0.85 | MAP3K7 (0.66) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL31684776 | 0.85 | MAP3K7 (0.70) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL28980973 | 0.85 | MAP3K7 (0.70) | MAP3K7MAP2K1MAPK1FGFR1SRC | |
| SCHEMBL31684746 | 0.84 | JAK3 (0.71) | MAP3K7MAP2K1MAPK1FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |