Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 8/20 | 0.80 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.80 |
| ▸ | SRC | P12931 | 5/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.80 |
| ▸ | FLT3 | P36888 | 1/20 | 0.69 |
| ▸ | BTK | Q06187 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | BLK | P51451 | 1/20 | 0.65 |
| ▸ | BMX | P51813 | 1/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684777 | 1.00 | MAP3K7 (0.80) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL31684766 | 0.93 | MAP3K7 (0.73) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL28980998 | 0.93 | MAP3K7 (0.73) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL28980965 | 0.92 | MAP3K7 (0.81) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL28980986 | 0.91 | CCND3 (0.69) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL31684756 | 0.91 | CCND3 (0.69) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL31684798 | 0.91 | MAP3K7 (0.67) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL31684780 | 0.91 | MAP3K7 (0.70) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL28980991 | 0.91 | MAP3K7 (0.70) | MAP3K7MAP2K1SRCMAPK1FGFR1 | |
| SCHEMBL28980972 | 0.91 | MAP3K7 (0.67) | MAP3K7MAP2K1SRCMAPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |