Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.71 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.64 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684746 | 1.00 | JAK3 (0.71) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL31684777 | 0.89 | MAP3K7 (0.80) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL28980982 | 0.89 | MAP3K7 (0.80) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL28980973 | 0.87 | MAP3K7 (0.70) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL31684776 | 0.87 | MAP3K7 (0.70) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL28980980 | 0.87 | JAK3 (0.61) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL31684785 | 0.86 | MAP3K7 (0.66) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL28980978 | 0.86 | MAP3K7 (0.66) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL31684766 | 0.86 | MAP3K7 (0.73) | JAK3MAP3K7MAP2K1MAPK1SRC | |
| SCHEMBL28980998 | 0.86 | MAP3K7 (0.73) | JAK3MAP3K7MAP2K1MAPK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |