Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822064 | 0.95 | ENPP1 (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL24714039 | 0.95 | ENPP1 (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL2453138 | 0.95 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL29465790 | 0.95 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL29465791 | 0.95 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL665187 | 0.95 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL28983518 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL29834791 | 0.89 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL29834734 | 0.89 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL28983517 | 0.89 | GPR119 (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115803326-B | EGFR inhibitor, preparation method thereof and application thereof in pharmacy | 上海和誉生物医药科技有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-115803326-A | EGFR inhibitor, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| WO-2022105908-A1 | EGFR INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2022-05-27 | — | — | WO | disclosed |