Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.36 |
| ▸ | PTGIR | P43119 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12337279 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2CHRM3 | |
| SCHEMBL13867376 | 0.80 | RAB9A (0.46) | SMN1; SMN2CHRM3 | |
| SCHEMBL2114252 | 0.77 | HRH1 (0.40) | CHRM3BCHELMNACARM1PRMT6 | |
| SCHEMBL2116387 | 0.77 | HRH3 (0.37) | SMN1; SMN2CHRM3HTR4LMNA | |
| SCHEMBL26493887 | 0.76 | NPC1 (0.41) | BCHEHTR4LMNA | |
| SCHEMBL26119845 | 0.76 | — | — | |
| SCHEMBL13867406 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2CHRM3 | |
| SCHEMBL21068872 | 0.74 | TSHR (0.50) | SMN1; SMN2LMNA | |
| SCHEMBL17247792 | 0.73 | TSHR (0.39) | — | |
| SCHEMBL15120686 | 0.73 | EPHX2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115803030-A | Compounds and methods for KRAS-targeted degradation | 阿维纳斯企业公司 | 2023-03-14 | — | — | CN | disclosed |
| EP-4132655-A1 | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS | Arvinas Operations, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |