SCHEMBL28985340

SCHEMBL28985340

Cc1ccc(N2CCC(NC(=O)C(=O)c3c[nH]c4cc(C(=O)O)ccc34)C2=O)c(Cl)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
B3GAT3 O94766 1/20 0.74
F10 P00742 7/20 0.40
CDK4 P11802 2/20 0.36
CCND1 P24385 2/20 0.36
NR4A2 P43354 1/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
IGF1R P08069 1/20 0.36
MET P08581 1/20 0.36
RAB9A P51151 1/20 0.35
PRKAB2 O43741 1/20 0.35
PRKAG1 P54619 1/20 0.35
PRKAA2 P54646 1/20 0.35
PRKAA1 Q13131 1/20 0.35
PRKAG3 Q9UGI9 1/20 0.35
PRKAG2 Q9UGJ0 1/20 0.35
PRKAB1 Q9Y478 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC8 Q9BY41 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28984922 0.93 B3GAT3 (0.85) B3GAT3CDK4CCND1NR4A2RAB9A
SCHEMBL28984926 0.92 B3GAT3 (0.88) B3GAT3F10CDK4CCND1NR4A2
SCHEMBL29504777 0.88 B3GAT3 (0.76) B3GAT3CDK4CCND1TP53MAPT
SCHEMBL30267518 0.85 B3GAT3 (1.00) B3GAT3CDK4CCND1NR4A2TP53
SCHEMBL28984929 0.85 B3GAT3 (1.00) B3GAT3CDK4CCND1NR4A2TP53
SCHEMBL29504687 0.85 B3GAT3 (0.79) B3GAT3CDK4CCND1NR4A2
SCHEMBL29504713 0.85 B3GAT3 (0.79) B3GAT3CDK4CCND1NR4A2TP53
SCHEMBL29504741 0.85 B3GAT3 (0.79) B3GAT3CDK4CCND1
SCHEMBL28984931 0.85 B3GAT3 (0.79) B3GAT3CDK4CCND1NR4A2TP53
SCHEMBL28984921 0.85 B3GAT3 (0.79) B3GAT3CDK4CCND1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115974849-A Indoxyl acetamide derivative, pharmaceutical composition containing indoxyl acetamide derivative and application of indoxyl acetamide derivative 中国药科大学 2023-04-18 CN claimed
CN-115974849-B Indolyloxy acetamide derivative, pharmaceutical composition containing same and application of pharmaceutical composition 中国药科大学 2024-06-21 CN disclosed
CN-115974849-A Indoxyl acetamide derivative, pharmaceutical composition containing indoxyl acetamide derivative and application of indoxyl acetamide derivative 中国药科大学 2023-04-18 CN disclosed