SCHEMBL28985367

SCHEMBL28985367

Oc1cccc(-c2ccn(Br)n2)c1

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSD17B2 P37059 8/20 0.52
HSD17B1 P14061 8/20 0.52
FYN P06241 9/20 0.49
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
METAP2 P50579 1/20 0.45
GABRA1 P14867 1/20 0.41
GABRB2 P47870 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3324191 0.80 KMT2A (0.60) HSD17B2HSD17B1FYNCYP3A4CYP2C9
SCHEMBL28073890 0.79 HSD17B2 (0.52) HSD17B2HSD17B1FYNCYP3A4CYP2C9
SCHEMBL27976160 0.77 KMT2A (0.59) GABRA1
SCHEMBL27277684 0.75 HSD17B2 (0.47) HSD17B2HSD17B1FYNCYP3A4CYP2C9
SCHEMBL23951310 0.70 HSD17B2 (0.42) HSD17B2HSD17B1FYNCYP3A4CYP2C9
SCHEMBL30862097 0.70 HSD17B1 (0.66) HSD17B2HSD17B1CYP3A4CYP2C9METAP2
SCHEMBL1180306 0.69 HSD17B1 (1.00) HSD17B2HSD17B1FYNCYP3A4CYP2C9
SCHEMBL69369 0.68 HSD17B1 (0.88) HSD17B2HSD17B1CYP3A4CYP2C9
SCHEMBL29551999 0.68 HSD17B1 (0.88) HSD17B2HSD17B1CYP3A4CYP2C9
SCHEMBL8050006 0.66 HSD17B1 (0.94) HSD17B2HSD17B1CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115819348-A Process for preparing N-arylpyrazole compound 曲靖师范学院 2023-03-21 CN disclosed