SCHEMBL28985446

SCHEMBL28985446

O=C(O)c1nn(CCCCBr)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
PMP22 Q01453 1/20 0.50
HIF1A Q16665 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CNR1 P21554 7/20 0.49
CNR2 P34972 5/20 0.49
HSD17B10 Q99714 2/20 0.49
KDM4E B2RXH2 1/20 0.49
PARP1 P09874 1/20 0.46
PTGER4 P35408 3/20 0.45
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HTR3A P46098 1/20 0.41
ELANE P08246 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6948768 0.86 CNR1 (0.61) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL30497875 0.86 CNR1 (0.61) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL15897852 0.85 TSHR (0.52) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL28985448 0.84 CNR1 (0.66) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL2818345 0.84 CNR1 (0.60) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL13690858 0.82 TSHR (0.47) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL4050608 0.82 CNR1 (0.52) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL31429522 0.82 TSHR (0.54) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL5438502 0.82 TSHR (0.54) TSHRCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL17599134 0.81 TNF (0.49) TSHRCNR1CNR2HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115784994-A Isotopic psychoactive substance labeled compound, preparation method and application thereof 公安部第三研究所 2023-03-14 CN claimed
CN-115784994-A Isotopic psychoactive substance labeled compound, preparation method and application thereof 公安部第三研究所 2023-03-14 CN disclosed