Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219605 | 1.00 | MAP3K14 (0.53) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL30219561 | 0.83 | MAP3K14 (0.50) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986271 | 0.83 | MAP3K14 (0.50) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986262 | 0.81 | MAP3K14 (0.49) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL30219568 | 0.81 | MAP3K14 (0.49) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986237 | 0.80 | MAPKAPK2 (0.53) | MAP3K14MAPKAPK2PTK2FGFR1JAK2 | |
| SCHEMBL30219596 | 0.80 | MAPKAPK2 (0.53) | MAP3K14MAPKAPK2PTK2FGFR1JAK2 | |
| SCHEMBL28986246 | 0.74 | MAPKAPK2 (0.57) | MAP3K14MAPKAPK2CDC7CDK2ROCK1 | |
| SCHEMBL25402204 | 0.72 | MAPKAPK2 (0.55) | MAP3K14MAPKAPK2CDC7CDK2ROCK1 | |
| SCHEMBL30219555 | 0.72 | MAPKAPK2 (0.55) | MAP3K14MAPKAPK2CDC7CDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-B | Compound with 2-aminopyrimidine structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-01-24 | — | — | CN | disclosed |